HIV Coreceptor Downregulation as Antiviral Principle: SDF-1 a –dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication
نویسندگان
چکیده
From the * Unité d’Immunologie Virale and ‡ Laboratoire Rétrovirus et Transfert Génétique, Institut Pasteur, 75724 Paris, Cedex 15, France; § Laboratoire Mécanismes Moléculaires du Transport Intracellulaire, Centre National de la Recherche Scientifique UMR 144, Institut Curie, 75248 Paris Cedex 05, France; i Laboratoire d’Immunologie Cellulaire, Centre National de la Recherche Scientifique URA 625, CERVI, 75013 Paris, France; and ¶ Theodor Kocher Institute, University of Bern, CH-3000 Bern 9, Switzerland
منابع مشابه
HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication
Ligation of CCR5 by the CC chemokines RANTES, MIP-1alpha or MIP-1beta, and of CXCR4 by the CXC chemokine SDF-1alpha, profoundly inhibits the replication of HIV strains that use these coreceptors for entry into CD4(+) T lymphocytes. The mechanism of entry inhibition is not known. We found a rapid and extensive downregulation of CXCR4 by SDF-1alpha and of CCR5 by RANTES or the antagonist RANTES(9...
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